Axons in the desert International Workshop

Transcription

1 International Workshop Ben-Gurion University of the Negev & Kibbutz Ein Gedi, Israel November, 2013 Sponsored by: Zlotowski Center for Neuroscience

2 24-26 November, 2013 Beer Sheva & Ein Gedi There has been a growing interest in various aspects of electrogenesis of central axons in both health and neurological disease. We therefore see this workshop as an opportunity to not only exchange our latest findings, but also to frankly confront controversies and try to resolve and understand some of the conflicting evidence that has arisen from studies entailing different techniques, experimental preparations and disciplines. Among the subjects we would like to address: What is the distribution of sodium channels of different subtype in soma-dendritic and axon initial segment membrane How should action potential generation be modeled and what parameters are lacking to make definitive models? What aspects of the axon initial segment are generalized to all cell types and what are specific to specific types? How do the protein-protein interactions that must occur in the complex axonal structure translate into function? What is the evidence for normal or pathogenic plasticity of the axon initial segment, what are the conditions under which this plasticity is seen, and what might be its functional consequence? Organizing Committee: Ilya Fleidervish, Ben-Gurion University of the Negev, Israel Mike Gutnick, The Hebrew University of Jerusalem, Israel Special thanks to Yana Khrapunsky and Shifra Zur-Aryhe for help in the organization. 2

3 List of Participants Gytis Baranauskaus, Ben Gurion University Alex Binshtok, The Hebrew University Juan Buronne, King's College London Matthew Grubb, King's College London Stefan Hallermann, University Leipzig Ilya Fleidervish, Ben Gurion University Alon Friedman, Ben Gurion University Josh Goldberg, The Hebrew University David Golomb, Ben Gurion University Mike Gutnick, The Hebrew University Hanoch Kaphzan, Haifa University Maarten Kole, Netherlands Institute for Neuroscience Mickey London, The Hebrew University Adi Mizrachi, The Hebrew University Alon Monsenego, Ben Gurion University Andreas Neef, MPI Göttingen Zoltan Nusser, Institute of Experimental Medicine, Budapest Idan Segev, The Hebrew University Menahem Segal, Weizmann Institute Maxim Volgushev, University of Connecticut Fred Wolf, MPI Göttingen Yoel Yaari, The Hebrew University

4 Conference Programme Sunday, November 24 - Beer Sheva Venue: Deichman Medical Sciences building (M6, Ctrl+Click the interactive map below), room :00 Get together, light refreshments 15:45 Welcome, Introduction and Logistics 16:00 Micha Spira, The Hebrew University, Jerusalem Assembly of a new growth cone after axotomy: the precursor to axon regeneration 17:00 Transportation to Lakiya 17:30 Gala Dinner in Beduin Tent, Lakiya (warm clothes recommendend, nights could be chilly in the Negev desert) 19:30 Transportation to Kibbutz Ein Gedi 4

5 Monday, November 25 07:00 08:00 Breakfast Session 1: Action potential properties and information encoding in neuronal circuits Chair: David Golomb 8:00 8:45 Fred Wolf, MPI for Dynamics and Self-Organization, Goettingen Coding by neuronal populations: why the precise details of action potential initiation are so important 8:45 9:30 Idan Segev, The Hebrew University, Jerusalem What do dendrites tell the axon? 9:30 10:15 Maxim Volgushev, University of Connecticut, Storrs, CT Action potential initiation and the speed of computations in neurons and neuron models 10:15 10:30 Coffee break Session 2: Ion channels and axonal excitability - I Chair: Alon Friedman 10:30 11:15 Zoltan Nusser, Institute of Experimental Medicine, Budapest Distinct cell surface distributions of voltage-gated ion channels 11:15 12:00 Ilya Fleidervish, Ben Gurion University, Beersheva Spatial mismatch between the Na + flux and spike initiation in axon initial segment 12:00 12:45 Maarten Kole, Netherlands Institute for Neuroscience, Amsterdam Nav-Kv7 coupling and the saltatory propagating action potential 12:45 13:45 Lunch Session 3: Ion channels and axonal excitability - II Chair: Josh Goldberg 13:45 14:30 Andreas Neef, MPI for Dynamics and Self-Organization, Goettingen Sodium channel properties, action potential waveform and information encoding in pyramidal cells 14:30 15:15 Mike Gutnick, The Hebrew University, Jerusalem Mechanisms of persistent Na + current generation in cortical pyramidal neurons 5

6 15:15 16:00 Stefan Hallermann, University Leipzig, Leipzig Kilohertz signalling in cerebellar mossy fiber axons 16:00 16:30 Mickey London, The Hebrew University, Jerusalem Spike initiation in Purkinje cell axons 16:30 16:45 Coffee break Session 4: Ion channels and axonal excitability - III Chair: Alex Binshtok 16:45 17:30 Yoel Yaari, The Hebrew University, Jerusalem Control of intrinsic excitability by perisomatic Kv7 and SK channels in hippocampal pyramidal cells 17:30 18:00 Menahem Segal, Weizmann Institute, Rehovot Axon Initial Segment: regulation by the cisternal organelle 18:00 18:30 Gytis Baranauskas, Ben Gurion University, Beersheva Inactivation properties of the axonal Na + channels 19:00 20:30 Festive Dinner 20:30 -- Posters, Wine & Fruits 6

7 Tuesday, November 26 07:00 08:00 Breakfast Session 5: Axon initial segment plasticity in health and disease. Chair: Menahem Segal 8:00 8:45 Matthew Grubb, King's College London Rapid activity-dependent plasticity at the axon initial segment 8:45 9:30 Juan Buronne, King's College London Multiple forms of activity-dependent plasticity at the axon initial segment 9:30 10:15 Hanoch Kaphzan, Haifa University Axon initial segment alterations in the autistic mouse model of Angelman Syndrome 10:15 10:30 Coffee break 10:30 12:30 General discussion. Moderators: Mike Gutnick and Fred Wolf 12:30 13:30 Lunch Hike in En Gedi National Reserve? Dead Sea? Botanic Garden? Kibbutz? 13:30 17:00 17:00 Transportation to Beer Sheva 18:00 departure 7

8 Poster Session, November SICM images of the Axon-Initial-Segment for precise eap recording Ulrich Fromme, Georg-August-Universität, Goettingen 2. Axon Initial Segment: regulation by the cisternal organelle David Hofmann, MPI for Dynamics and Self-Organization, Goettingen 3. The Axon Initial Segment in a Model of a Neocortical Microcircuit Werner Van Geit, Etay Hay, Eilif Muller, Idan Segev and Henry Markram, EPFL Blue Brain Project, Lausanne & The Hebrew University of Jerusalem 4. Differentiation between somatic and axonal sodium channels Efrat Katz, The Hebrew University of Jerusalem 8